1. Discipline had no effect on him as a child. He has always misbehaved.
2. The public transport strike won’t affect me. I go to work by bike.
3. The morphine took immediate effect. As soon as they gave it to me the pain went away.
4. Use the word affect as a verb and effect is more common as a noun. So, the bad weather really affected our holiday, and the snow had a big effect on our holiday.

affect = afectar
effect = consecuencia